Eksigent Citations

NanoLC Precision in Proteomic Analyses
Don W. Arnold, Ph.D
Genetic Engineering & Biotechnology News, Drug Discovery Channel. Jan 1 2010 (Vol. 30, No. 1)
Jan 2010

HPLC at the Micro Scale
Don W. Arnold, Ph.D
Innovations in Pharmaceutical Technology, Analytical Lab Technology, December 2009
Dec 2009

Application of Microbore UHPLC—MS-MS to the Quantitation of In Vivo Pharmacokinetic Study Samples
David Neyer and Steve Hobbs
Spectroscopy Solutions for Materials Analysis, Special Issues, Jul 1, 2009
Jul 2009

On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets
N. Reginald Beer, Elizabeth K. Wheeler, Lorenna Lee-Houghton, Nicholas Watkins, Shanavaz Nasarabadi, Nicole Hebert, Patrick Leung, Don W. Arnold, Christopher G. Bailey, and Bill W. Colston
Anal. Chem., 80 (6), 1854 -1858, 2008. 10.1021/ac800048k S0003-2700(80)00048-0
Feb 2008

Mobile Tool for HPLC Reaction Monitoring
Wes A. Schafer, Steve Hobbs, Jason Rehm, David A. Rakestraw, Charles Orella, Mark McLaughlin, Zhihong Ge, and Christopher J. Welch
Organic Process R&D
Aug 2007

Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis
Sajonz P, Schafer W, Gong X, Shultz S, Rosner T, Welch CJ
Journal of Chromatography A, Volume 1145, Issues 1-2 , 23 March 2007, Pages 149-154
Mar 2007

Hair Bundles Are Specialized for ATP Delivery via Creatine Kinase
Shin JB, Streijger F, Beynon A, Peters T, Gadzala L, McMillen D, Bystrom C, Van der Zee CEEM, Wallimann T, Gillespie PG
Neuron, Volume 53, Issue 3 , 1 February 2007, Pages 371-386
Feb 2007

Quantitative proteomic profiling of sarcomere associated proteins in limb and extraocular muscle allotypes.
Fraterman S, Zeiger U, Khurana TS, Wilm M, Rubinstein NA
Mol Cell Proteomics. 2007 6: 728
Jan 2007

Laser flash photochemical oxidation to locate heme binding and conformational changes in myoglobin
Hambly D, Gross M
International Journal of Mass Spectrometry, Volume 259, Issues 1-3 , 1 January 2007, Pages 124-129
Jan 2007

Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.
Cassidy PB, Edes K, Nelson CC, Parsawar K, Fitzpatrick FA, Moos PJ
Carcinogenesis. 2006 Dec;27(12):2538-49. Epub 2006 Jun 15
Dec 2006

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80
Dec 2006

Multiparallel chiral method development screening using an 8-channel microfluidic HPLC system
Sajonz P, Gong X, Leonard WR Jr, Biba M, Welch CJ
Chirality. 2006 Nov;18(10):803-13
Nov 2006

Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons.
Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM
J Biol Chem. 2006 Oct 27;281(43):32879-90
Oct 2006

A Method for Automatically Interpreting Mass Spectra of 18O-Labeled Isotopic Clusters
Mason CJ, Therneau TM, Eckel-Passow JE, Johnson KL, Oberg AL, Olson JE, Nair KS, Muddiman DC, Bergen HR
Molecular & Cellular Proteomics 6:305-318, 2007
Oct 2006

The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function.
Gagnon LH, Longo-Guess CM, Berryman M, Shin JB, Saylor KW, Yu H, Gillespie PG, Johnson KR
J Neurosci. 2006 Oct 4;26(40):10188-98
Oct 2006

Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin
Sapra R, Gaucher SP, Lachmann JS, Buffleben GM, Chirica GS, Comer JE, Peterson JW, Chopra AK, Singh AK
Microbial Pathogenesis, Volume 41, Issues 4-5 , October-November 2006, Pages 157-167
Oct 2006

The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules.
Kozak SL, Marin M, Rose KM, Bystrom C, Kabat D
J Biol Chem. 2006 Sep 29;281(39):29105-19. Epub 2006 Aug 3
Aug 2006

Design Considerations for High Speed Quantitative Mass Spectrometry with MALDI Ionization
Corr JJ, Kovarik P, Schneider BB, Hendrikse J, Loboda A, Covey TR
Journal of the American Society for Mass Spectrometry, Volume 17, Issue 8 , August 2006, Pages 1129-1141
Aug 2006

A computational approach toward label-free protein quantification using predicted peptide detectability.
Tang H, Arnold RJ, Alves P, Xun Z, Clemmer DE, Novotny MV, Reilly JP, Radivojac P
Bioinformatics. 2006 Jul 15;22(14):e481-8
Jul 2006

Characterization of the capsid protein glycosylation of adeno-associated virus type 2 by high-resolution mass spectrometry.
Murray S, Nilsson CL, Hare JT, Emmett MR, Korostelev A, Ongley H, Marshall AG, Chapman MS
J Virol. 2006 Jun;80(12):6171-6
Jun 2006

Interaction of Cytochrome C With A-Crystallin in the Early Phase of Experimental Autoimmune Uveitis
Katselis GS, Wu GS, Moore RE, Rao NA, Lee TD
Invest Ophthalmol Vis Sci 2006;47: E-Abstract 4571
Jun 2006

Expression of and secretion through the Aeromonas salmonicida type III secretion system
Ebanks RO, Knickle LC, Goguen M, Boyd JM, Pinto DM, Reith M, Ross NW
Microbiology 152 (2006), 1275-1286
May 2006

Miniaturization: Chip-based liquid chromatography and proteomics
Gauthier GL, Grimm R
Drug Discovery Today: Technologies, Volume 3, Issue 1 , Spring 2006, Pages 59-66
Apr 2006

Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins.
Anderson L, Hunter CL
Mol Cell Proteomics. 2006 Apr;5(4):573-88
Apr 2006

Immobilized enzyme reactor chromatography: Optimization of protein retention and enzyme activity in monolithic silica stationary phases
Besanger TR, Hodgson RJ, Green JRA, Brennan JD
Analytica Chimica Acta, Volume 564, Issue 1 , 30 March 2006, Pages 106-115
Mar 2006

Monolithic membrane-receptor columns: Optimization of column performance for frontal affinity chromatography/mass spectrometry applications
Besanger TR, Hodgson RJ, Guillon D, Brennan JD
Analytica Chimica Acta, Volume 561, Issues 1-2 , 2 March 2006, Pages 107-118
Mar 2006

I-Ep-bound self-peptides: identification, characterization, and role in alloreactivity.
Felix NJ, Suri A, Walters JJ, Horvath S, Gross ML, Allen PM
J Immunol. 2006 Jan 15;176(2):1062-71
Jan 2006

Structural Analysis of K-Carrageenan Sulfated Oligosaccharides by Positive Mode Nano-ESI-FTICR-MS and MS/MS by SORI-CID
Aguilan JT, Dayrit FM, Zhang J, Ni
Journal of the American Society for Mass Spectrometry, Volume 17, Issue 1 , January 2006, Pages 96-103
Jan 2006

Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.
Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM
Mol Cell Proteomics. 2005 Dec;4(12):2000-9
Dec 2005

Reproducibility of retention time using a splitless nanoLC coupled to an ESI-FTICR mass spectrometer.
Mason CJ, Johnson KL, Muddiman DC
J Biomol Tech. 2005 Dec;16(4):414-22
Dec 2005

Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure.
Hawkridge AM, Heublein DM, Bergen HR 3rd, Cataliotti A, Burnett JC Jr, Muddiman DC
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17442-7
Nov 2005

Atg19p Ubiquitination and the Cytoplasm to Vacuole Trafficking Pathway in Yeast
Baxter BK, Abeliovich H, Zhang|| X, Stirling AG, Burlingame AL, Goldfarb DS
J. Biol. Chem., Vol. 280, Issue 47, 39067-39076
Nov 2005

A Combinatorial Code for the Interaction of -Synuclein with Membranes
Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL
J. Biol. Chem., Vol. 280, Issue 36, 31664-31672
Sep 2005

Proteomic Analysis of Schistosoma mansoni Cercarial Secretions
Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH
Molecular & Cellular Proteomics 4:1862-1875, 2005
Aug 2005

Genome-Wide Screen for Inner Nuclear Membrane Protein Targeting in Saccharomyces cerevisiae: Roles for N-Acetylation and an Integral Membrane Protein
Murthi A, Hopper AK
Genetics, Vol. 170, 1553-1560, August 2005
Aug 2005

An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.
Ippolito JE, Xu J, Jain S, Moulder K, Mennerick S, Crowley JR, Townsend RR, Gordon JI
Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9901-6
Jul 2005

The Met-Tyr-Trp Cross-link in Mycobacterium tuberculosis Catalase-peroxidase (KatG): AUTOCATALYTIC FORMATION AND EFFECT ON ENZYME CATALYSIS AND SPECTROSCOPIC PROPERTIES
Ghiladi RA, Knudsen GM, Medzihradszky KF, de Montellano PRO
J. Biol. Chem., Vol. 280, Issue 24, 22651-22663
Apr 2005

Laser Flash Photolysis of Hydrogen Peroxide to Oxidize Protein Solvent-Accessible Residues on the Microsecond Timescale
Hambly DM, Gross ML
Journal of the American Society for Mass Spectrometry, Volume 16, Issue 12 , December 2005, Pages 2057-2063
Jan 2005

Instrumentation for advanced microseparations in pharmaceutical analysis and proteomics
Rozing G, N
Journal of Biochemical and Biophysical Methods, Volume 60, Issue 3 , 30 September 2004, Pages 233-263
Sep 2004

Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS).
Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL
Molecular & Cellular Proteomics 3:872-886, 2004
Sep 2004

Protein identification by liquid chromatography?mass spectrometry using retention time prediction
Palmblad M, Ramstr
Journal of Chromatography B, Volume 803, Issue 1 , 15 April 2004, Pages 131-135
Apr 2004

Microchip-based systems for target validation and HTS
Sundberg SA, Chow A, Nikiforov T, Wada HG
Drug Discovery Today, Volume 5, Supplement 12 , 2000, Pages S92-S103
Oct 2000

Comparison of Multiparallel Microfluidic HPLC Instruments for High Throughput Analyses in Support of Pharmaceutical Process Research
Welch, Christopher1; Sajonz, Peter1; Biba, Mirlinda1; Gouker, Joe1; Fairchild, Jacob1
Journal of Liquid Chromatography & Related Technologies, Volume 29, Number 15, 2006 , pp. 2185-2200(16)


Challenges and Opportunities for the Greening of Separation Science in the Pharmaceutical Industry
Dr. Christopher J. Welch
Drug Discovery World, Fall 2007


The use of dual cHiPLC columns to increase throughput in quantitative peptide MRM analyses
The use of dual cHiPLC columns to increase throughput in quantitative peptide MRM analyses



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