NanoLC Systems

NanoLC Systems

Developed specifically for nanospray mass spectrometry (MS), Eksigent NanoLC systems provide speed, sensitivity, resolution and reliability for your research.

NanoLC systems employ Eksigent's Microfluidic Flow Control (MFC) technology, which creates rapid, reproducible, low-flow-rate binary gradients using continuous flow measurement in combination with a controlled pressure source. Measurement of temperature allows the NanoLC systems to adjust for viscosity changes over extended run times and produces excellent retention time reproducibility day-to-day and month-to-month, for improved identification of low-abundance proteins. And since there is no flow splitting, flow inaccuracies and retention-time variability caused by splitter-based systems are eliminated.

The system also incorporates Eksigent's peak parking capability, which allows the flow rate to be changed rapidly for higher speed sample loading or for extended MS/MS analysis to identify co-eluting and low abundance peptides. Binary solvent delivery, high pressure gradient mixing, autosampler, and PC-based instrument control are all available in our compact NanoLC systems.

With instruments designed for one-dimensional and two-dimensional applications, Eksigent NanoLC systems offer outstanding flexibility, throughput, and ease-of-use with Eksigent LC Control Software. And you can team up your NanoLC system with a mass spectrometer to improve ease-of-use, data integrity, and reliability.

  • NanoLC-Ultra® System - The NanoLC-Ultra family of high pressure HPLCs deliver superior gradient precision at pressures up to 10,000 psi.
  • NanoLC™-1D Plus & 2D Plus Systems - Eksigent’s second-generation NanoLC™ system delivers stable, reproducible separations for peptide/protein identification, biomarker discovery, protein characterization and more.
  • NanoFlow Metering System - Handle small volume samples with unprecedented precision at flow rates from 1 nL/min to 10 µL/min and backpressures to 3,000 psi